Table 5.
ECemble predicted enzymes from reviewed human proteome.
| Gene Name | Accession | $UniProt Annotation | New ECemble Prediction |
EC Description of
Enzyme Function |
|---|---|---|---|---|
| DHRS7 | Q9Y394 | 1.1.-.- | 1.1.1.n4* | (-)-trans-carveol dehydrogenase |
| GFOD1 | Q9NXC2 | 1.-.-.- | 1.1.1.n6* | D-chiro-inositol 3-dehydrogenase |
| FOXRED1 | Q96CU9 | 1.-.-.- | 1.1.5.4* | Malate dehydrogenase (quinone) |
| ALOX12B | O75342 | 1.13.11.- | 1.13.11.12* | Linoleate 13S-lipoxygenase |
| ALDH8A1 | Q9H2A2 | 1.2.1.- | 1.2.1.16* | Succinate-semialdehyde dehydrogenase (NAD(P)(+)) |
| SCCPDH | Q8NBX0 | 1.-.-.- | 1.5.1.10* | Saccharopine dehydrogenase (NADP(+), L-glutamate-forming) |
| TFB1M | Q9UNQ2 | 2.1.1.- | 2.1.1.182* | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase |
| METTL15 | A6NJ78 | 2.1.1.- | 2.1.1.199* | 16S rRNA (cytosine(1402)-N(4))-methyltransferase |
| METTL15P1 | P0C7V9 | 2.1.1.- | 2.1.1.199* | 16S rRNA (cytosine(1402)-N(4))-methyltransferase |
| PYROXD2 | Q8N2H3 | 1.-.-.- | 2.1.1.74* | (FADH(2)-oxidizing) |
| GOT1L1 | Q8NHS2 | 2.6.1.- | 2.6.1.9* | Histidinol-phosphate transaminase |
| FGGY | Q96C11 | 2.7.1.- | 2.7.1.16* | Ribulokinase |
| ISPD | A4D126 | 2.7.7.- | 2.7.7.60* | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
| GDPD3 | Q7L5L3 | 3.1.-.- | 3.1.4.46* | Glycerophosphodiester phosphodiesterase |
| TLL1 | O43897 | 3.4.24.- | 3.4.24.21* | Astacin |
| TASP1 | Q9H6P5 | 3.4.25.- | 3.4.25.2* | HslU--HslV peptidase |
| ADAL | Q6DHV7 | 3.5.4.- | 3.5.4.2* | Adenine deaminase |
| IREB2 | P48200 | None | 4.2.1.33* | 3-isopropylmalate dehydratase |
| TYRP1 | P17643 | 1.14.18.- | 1.14.11.13** | Gibberellin 2-beta-dioxygenase |
| HSD11B2 | P80365 | 1.1.1.- | 1.3.1.9** | Enoyl-[acyl-carrier-protein] reductase (NADH) |
| NDOR1 | Q9UHB4 | 1.6.-.- | 1.8.1.2** | Sulfite reductase (NADPH) |
| ENDOV | Q8N8Q3 | 3.1.26.- | 3.1.21.7** | Deoxyribonuclease V |
| ENPP5 | Q9UJA9 | 3.1.-.- | 3.6.1.27** | Undecaprenyl-diphosphate phosphatase |
| MPPED2 | Q15777 | 3.1.-.- | 3.6.1.41** | Bis(5'-nucleosyl)-tetraphosphatase (symmetrical) |
| THNSL2 | Q86YJ6 | 4.2.3.- | 4.2.1.20** | Tryptophan synthase |
| ALOXE3 | Q9BYJ1 | 5.4.4.- | 1.13.11.12*** | Linoleate 13S-lipoxygenase |
| ABHD2 | P08910 | 3.1.1.- | 2.3.1.31*** | Homoserine O-acetyltransferase |
| ABHD1 | Q96SE0 | 3.1.1.- | 2.3.1.31*** | Homoserine O-acetyltransferase |
| ABHD3 | Q8WU67 | 3.1.1.- | 2.3.1.84*** | Alcohol O-acetyltransferase |
| SDR42E1 | Q8WUS8 | 1.1.1.- | 5.1.3.20*** | ADP-glyceromanno-heptose 6-epimerase |
$Current annotation is based on UniProt database
n Preliminary EC numbers include an 'n' as part of the fourth digit in ENZYME database
* Good predictions that complement the current annotations
** Predictions that differ from the current annotations only at the subclass level
*** Predictions that differ from the current annotations at the class level