Table 2.
DNA-damaging agent | Mechanism of action | IRIF/cell relative to IR + DMSO
|
|
---|---|---|---|
50 μM | 6.25 μM | ||
Temozolomide | Base alkylation | 2.57 | 1.04 |
Pipobroman | Base alkylation | 2.55 | 1.25 |
Thiotepa | Base alkylation | 2.43 | 1.50 |
Chlorambucil | Base alkylation | 2.30 | 1.30 |
Benzophenanthridine | Topoisomerase II inhibitor | 2.36 | 0.60 |
Teniposide | Topoisomerase II inhibitor | 1.66 | 0.93 |
Etoposide | Topoisomerase II inhibitor | 0.41 | 1.95 |
Mitoxantrone | Topoisomerase II inhibitor | Toxic | 0.20 |
Cisplatin | Intrastrand crosslinker | 2.12 | 0.93 |
Oxaliplatin | Intrastrand crosslinker | 1.93 | 1.08 |
Carboplatin | Intrastrand crosslinker | 1.59 | 1.26 |
Bleomycin | Interstrand crosslinker | 3.31 | 1.71 |
Thioguanine | Purine synthesis inhibitor | 3.39 | 1.60 |
Pentostatin | Adenosine deaminase inhibitor | 1.57 | 0.63 |
Cladribine | Adenosine deaminase inhibitor | 1.65 | 1.42 |
Deoxyadenosine | Adenosine deaminase inhibitor | 1.75 | 1.17 |
Doxorubicin | Alkylator | 1.12 | 2.12 |
Valrubicin | Alkylator | 1.88 | 1.46 |
Cytaribine | DNA polymerase inhibitor | 2.42 | 1.92 |
Docetaxel | Tubulin stabilizer | 1.66 | 1.38 |
Arsenic trioxide | Thioredoxin reductase inhibitor | 3.42 | 1.54 |