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. 2015 Apr 10;34(11):1442–1444. doi: 10.15252/embj.201591553

Figure 1. Model for the functions of protrudin and FYCO1 in LE translocation and neurite outgrowth.

Figure 1

ER-localized protrudin forms contact sites with late endosomes (LEs) by coincident detection of Rab7 and PI(3)P (yellow) stopping LE movement (STOP). Kinesin-1 bound to protrudin is handed over to the LE protein FYCO1, which mediates plus-end (+)-directed LE movement (MOVE) along microtubules (MT) to the periphery. Synaptotagmin 7 (SYT7)-mediated LE fusion with the plasma membrane enables protrusion formation and neurite outgrowth.