Promoters of Myc-repressed genes contain SRF motifs. Example plots for two SRF gene sets found in the GSEA analysis of motif gene sets (C3, see
Supplementary Fig S7A for a list). The analysis was performed comparing cells expressing Myc-ER versus MycVD-ER. For one of these sets, the genes regulated in response to induction of Myc-ER are included as red dots in
Supplementary Fig S7B. ES = enrichment score; NES = normalized enrichment score; FDR = false discovery rate.