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. 2015 Jun 19;10(6):e0130348. doi: 10.1371/journal.pone.0130348

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Fig 5 — (A) Cross-sections at the middle of the spheroids were analyzed. (B) LSCM representative images of spheroid cross-sections, with different sizes, incubated with DOX for 0.5 h, 2 h, and 4 h. Scale bars, 100 μm. (C) Penetration area of DOX where the drug signals were detectable and normalized by area.