Fig 2. A. Binding of IgG to orexin and MCH neurons and CSF MCH levels in narcolepsy patients.

Co-localisation of serum IgG binding (green), orexin immunoreactivity (red) and MCH immunorecativity (purple) showed co-localization of IgG binding with both orexin and MCH neurons. B. MCH measurements in 8 available CSFs (including one without serum available) from post-H1N1-AS03-vaccinated orexin-deficient narcolepsy children compared with CSFs from 6 orexin-normal children.