Table 1. Clinical and methodological characteristics of included studies.
| First Author | PMID | Year | Country | Cases | Stage | Extracted Variables | Adjuvant therapy No. of patients (%) | Follow up Frequency (Months) | Follow up (Months) Median (Range) | CXCR4Localization | Cutt off value | HR Estimate | HR | 95% CI |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Koshiba | 10999740 | 2000 | Japan | 52 | I-IV | T,N,M,U | NS | NS | NS | cytoplasmic/ cell membrane | moderate | NA | NA | NA |
| Wehler | 17089032 | 2006 | Germany | 103 | I-IV | A,S,D,T,N, M,U | NS | NS | NS | cytoplasmic | strong | Sur. Curve (UV) | 1.19 | 0.74–1.92 |
| Maréchal | 19352387 | 2009 | Belgium | 71 | NS | A,S,D,T,N, M*,Le,Ve | 42 (59) | NS | NS | cytoplasmic | EI score>3 | MV | 2.54 | 1.27–5.10 |
| Cui | 20462600 | 2011 | China | 30 | I-IV | D,N,U | NS | NS | NS | cytoplasmic | upper quartile | NA | NA | NA |
| Gebauer | 21520098 | 2011 | Germany | 254 § | NS | A,S,D,T,N,M | 230 (92) | NS | NS | cytoplasmic | 5% | Sur. Curve (UV) | 1.03 | 0.70–1.50 |
| Kure | 22824809 | 2012 | Japan | 105 | NS | NA | 59 (56) | NS | 17.2 (0.4–153.1) | cytoplasmic | median (% of positive cells) | Sur. Curve (UV) | 0.76 | 0.48–1.18 |
| Liao | 23238349 | 2012 | Taiwan | 97 | I-II | A,S,D,T,N, M*,U,Lvi,Pn | 17 (18) | 3 | 26.3 Ф | cytoplasmic | >20% | MV | 1.78 | 1.02–3.09 |
| Bachet | 22377565 | 2012 | Belgium | 471 # | I-II | M $ | 252 (59) | 2–3 | 54 (1.1–143.7) | cytoplasmic | scale>2 | MV | 1.94 | 1.50–2.51 |
| Wang | 24023356 | 2013 | China | 48 | I-IV | A,S,D,N,U | NS | NS | 16.2 (NS) | cytoplasmic | NA | MV | 4.88 | 1.38–17.24 |
Abbreviation: A, age; D, differentiation; Lvi, lymphovascular invasion; Le, lymphatic embolus; M, distant metastasis; N, lymph node metastasis; Pn, perineural invasion; S, sex; T, depth of invasion; U, UICC stage; Ve, vascular embolus; NS, not specified
* liver metastasis specified as recurrence
$, distant recurrence without organ specification
# 428 patients in multivariate analysis
§ 249 patients evaluable
UV, univariate; MV, multivariate
Ф, only for 17 patients without recurrence or dead.