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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Am J Transplant. 2015 Feb 27;15(7):1768–1781. doi: 10.1111/ajt.13189

Figure 1. CsA does not protect the microvascular circulation of airway transplants.

Figure 1

(A) H&E staining (top row) and FITC-lectin perfusion (bottom row) of d14 allografts. CsA was administered at a dose of 25mg/kg/d. CsA partially protected the epithelial layer (top row), but did not preserve microvascular perfusion (bottom row). (B) BPU studies showed that CsA administered at doses of both 2.5 and 10mg/kg/d did not improve airway blood perfusion compared with controls (n=4–6 per group). The hatched line background represents values at which ischemia is demonstrated by FITC-lectin staining. BPUs are arbitrary values determined by the doppler flowmetry device. Scale bars, 20μm (A, top row) and 100μm (A, bottom row). Data are shown as mean±SEM.