Table 3. Significant single-SNP trans-ethnic meta-analysis results.
| Stratified Analysis P (MAF) | Meta-Analysis | Cochran’s Q | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
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| SNP | Gene | Chr | Position | AFA | CHN | EUR | HIS | Ref/Alt | Protein | Beta | SE | P | Stat | P |
| rs5745687 | HGF | 7 | 81359051 | 3.1E-04 (0.014) |
NA* (0.001) |
7.8E-12 (0.073) |
3.0E-04 (0.042) |
A/G | p.E299K | −89.1 | 10.5 | 2.88E-17 | 1.43 | 0.49 |
| rs16844364 | RGS12 | 4 | 3438643 | 0.014 (0.129) |
0.001 (0.451) |
0.045 (0.225) |
2.7E-06 (0.275) |
G/C | Intron | 29.7 | 4.9 | 1.98E-09 | 6.58 | 0.09 |
| rs4690098 | HGFAC | 4 | 3447156 | 0.771 (0.056) |
0.007 (0.445) |
5.3E-05 (0.226) |
8.4E-04 (0.230) |
T/C | Intron | −28.8 | 5.2 | 3.22E-08 | 4.16 | 0.24 |
| rs114303452 | HGFAC | 4 | 3449915 | NA* (0.002) |
NA* (0.000) |
2.9E-06 (0.017) |
3.4E-03 (0.005) |
G/A | p.K566R | 125.5 | 23.1 | 5.85E-08 | 1.07 | 0.30 |
| rs3748034 | HGFAC | 4 | 3446091 | 0.346 (0.046) |
0.007 (0.308) |
0.005 (0.144) |
9.7E-05 (0.127) |
C/A | p.A218S | 32.2 | 6.1 | 1.11E-07 | 3.20 | 0.36 |
AFA, African American; CHN, Chinese American; EUR, European American; HIS, Hispanic American; MAF, minor allele frequency; SE, standard error
*
Stratified analysis results not available for meta-analysis due to low empirical MAF.