Table 4. Haplotypic associations with PD.
| A. US series (895 patients, 976 controls)* | |||||
| Haplotype (rs56031549, del6, ins3, del21, rs2102808, rs4496303) | MAF in cases (%) | MAF in controls (%) | OR | P | P corr |
| 111112 | 0.96 | 1.25 | 0.68 (0.34–1.34) | 0.26 | 1 |
| 121221 | 5.3 | 4.62 | 1.17 (0.86–1.58) | 0.31 | 1 |
| 121121 | 8.59 | 6.71 | 1.4 (1.09–1.8) | 0.009 | 0.06 |
| 112111 | 2.64 | 1.74 | 1.63 (1.02–2.61) | 0.04 | 0.25 |
| 122111 | 12.93 | 14.42 | 0.86 (0.71–1.04) | 0.11 | 0.66 |
| 111111 | 69.58 | 71.27 | 0.91 (0.78–1.05) | 0.18 | 1 |
| B. Irish series (368 patients, 368 controls)* | |||||
| Haplotype (rs56031549, del6, ins3, del21, rs2102808, rs4496303) | MAF in cases (%) | MAF in controls (%) | OR | P | P corr |
| 111112 | 1.19 | 0.68 | 1.86 (0.55–6.28) | 0.32 | 1 |
| 121221 | 6.96 | 5.69 | 1.18 (0.77–1.81) | 0.45 | 1 |
| 121121 | 6.99 | 5.58 | 1.23 (0.81–1.88) | 0.34 | 1 |
| 112111 | 2.67 | 2.74 | 0.91 (0.47–1.78) | 0.79 | 1 |
| 122111 | 10.05 | 10.86 | 0.92 (0.65–1.32) | 0.66 | 1 |
| 111111 | 69.67 | 72.07 | 0.93 (0.73–1.18) | 0.54 | 1 |
| C. Polish series (713 patients, 252 controls)* | |||||
| Haplotype (rs56031549, del6, ins3, del21, rs2102808, rs4496303) | MAF in cases (%) | MAF in controls (%) | OR | P | P corr |
| 111112 | 1.03 | 1.87 | 0.46 (0.2–1.09) | 0.08 | 0.46 |
| 121221 | 6.85 | 7.4 | 0.97 (0.64–1.46) | 0.87 | 1 |
| 121121 | 7.17 | 5.11 | 1.45 (0.9–2.34) | 0.13 | 0.78 |
| 112111 | 2.2 | 2.22 | 1.07 (0.55–2.08) | 0.84 | 1 |
| 122111 | 14.97 | 14.39 | 1.05 (0.78–1.41) | 0.75 | 1 |
| 111111 | 67.78 | 69 | 0.93 (0.74–1.17) | 0.53 | 1 |
| D. Combined series (1976 patients, 1596 controls)* | |||||
| Haplotype (rs56031549, del6, ins3, del21, rs2102808, rs4496303) | MAF in cases (%) | MAF in controls (%) | OR | P | P corr |
| 111112 | 1.03 | 1.26 | 0.74 (0.46–1.21) | 0.23 | 1 |
| 121221 | 6.15 | 5.33 | 1.1 (0.9–1.35) | 0.36 | 1 |
| 121121 | 7.86 | 6.27 | 1.35 (1.11–1.64) | 0.003 | 0.02 |
| 112111 | 2.52 | 2.1 | 1.3 (0.93–1.81) | 0.12 | 0.71 |
| 122111 | 13.19 | 13.66 | 0.92 (0.8–1.06) | 0.27 | 1 |
| 111111 | 69.24 | 71.39 | 0.91 (0.82–1.02) | 0.1 | 0.57 |
Haplotypes are encoded as 1 for major allele and 2 for minor allele see Table 2 for specific alleles, MAF = minor allele frequency, OR = Odds ratio, CI = confidence interval, P = p-value, P corr = P-value with Bonferroni correction. ORs, 95% CIs, and P-values result from haplotype-based logistic regression analysis.
*Numbers of samples with complete clinical information included in model.