Table 2. The estimated number and percentage of participants virally suppressed (VL <200) at month 24 using the omit-participant, set-to-failure, and closest-VL analysis performed within the SMVL framework using data from the RIC study.
| Characteristic | Omit-participant (N = 551) | Set-to-Failure (N = 720) | Closest-VL (N = 720) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number VL <200 | Percent (95% CI) | Risk Ratio (RR) | RR 95% CI | Number VL <200 | Percent (95% CI) | Risk Ratio (RR) | RR 95% CI | Number VL <200 | Percent (95% CI) | Risk Ratio (RR) | RR 95% CI | |
| Overall | 324 | 58.8 (54.8, 63.1) | NA | NA | 324 | 45.0 (41.5, 48.8) | NA | NA | 390 | 54.2 (50.7, 57.9) | NA | NA |
| Age (years) | ||||||||||||
| 18–29 | 35 | 47.9 (36.8, 59.3) | REF | 35 | 33.0 (24.8, 42.5) | REF | 46 | 43.4 (34.3, 53.0) | REF | |||
| 30–39 | 73 | 57.9 (49.2, 66.2) | 1.21 | 0.91, 1.60 | 73 | 42.4 (35.3, 49.9) | 1.29 | 0.93, 1.77 | 91 | 52.9 (45.4, 60.3) | 1.22 | 0.94, 1.58 |
| 40+ | 216 | 61.5 (56.3, 66.5) | 1.28 | 0.997, 1.65 | 216 | 49.0 (44.3, 53.6) | 1.48 | 1.11, 1.98 | 253 | 57.4 (52.7, 61.9) | 1.32 | 1.05, 1.67 |
| Race / Ethnic | ||||||||||||
| White | 41 | 70.7 (57.8, 80.9) | REF | 41 | 51.3 (40.4, 62.0) | REF | 51 | 63.8 (52.7, 73.5) | REF | |||
| Black | 226 | 55.0 (50.2,59.7) | 0.78 | 0.65, 0.94 | 226 | 42.9 (38.7, 47.2) | 0.84 | 0.66, 1.06 | 270 | 51.2 (47.0, 55.5) | 0.80 | 0.67, 0.97 |
| Other | 10 | 76.9 (47.9, 92.4) | 0.96 | 0.76, 1.21 | 10 | 47.6 (27.9, 68.2) | 0.93 | 0.57, 1.53 | 12 | 57.1 (36.0, 76.0) | 0.90 | 0.60, 1.34 |
| Hispanic | 47 | 68.1 (56.3, 78.0) | 1.09 | 0.77, 1.53 | 47 | 51.1 (41.0, 61.1) | 1.00 | 0.74, 1.34 | 57 | 62.0 (51.7, 71.3) | 0.97 | 0.77, 1.22 |
| ART Baseline | ||||||||||||
| Yes | 181 | 57.1 (51.6, 62.4) | 0.93 | 0.81, 1.07 | 181 | 43.7 (39.0, 48.5) | 0.94 | 0.80, 1.10 | 216 | 52.2 (47.4, 57.0) | 0.92 | 0.80, 1.05 |
| No | 143 | 61.1 (54.7, 67.2) | REF | 143 | 46.7 (41.2, 52.3) | REF | 174 | 56.9 (51.3, 62.3) | REF | |||
| ART Baseline + 12 months | ||||||||||||
| Yes | 294 | 60.5 (56.1, 64.8) | 1.31 | 0.998, 1.72 | 294 | 46.2 (42.4, 50.1) | 1.29 | 0.96, 1.75 | 357 | 56.1 (52.3, 59.9) | 1.43 | 1.09, 1.88 |
| No | 30 | 46.2 (34.5, 58.3) | REF | 30 | 35.7 (26.2, 46.5) | REF | 33 | 39.3 (29.5. 50.1) | REF | |||
The ART baseline and ART baseline +12 months are defined as the participant being on ART at the start of the study and either at the start of study or the first 12 months of the study, respectively.
Notes: The omit-participant method removes participants from the analysis who do not have a VL within the 12-month “window” (-6/+2 months) around month 24. The set-to-failure method sets all VL for those participants without a VL measurement within the “window” to non-suppressed (failure). Lastly, the closest-VL method uses the closest VL measurement for each participant to month 24.