Fig 6. Cell fate map in response to activating or inhibitory signals of the TSRN model.

The attractors of the network were transiently perturbed in all possible micro-environments. Perturbations were considered activations (0 → 1) when a previously inactive element was turned on, and inhibitions (1 → 0) when a previously active element was turned off. The nodes represent CD4+ T cell types, and the node sizes correspond to the size of the basin of attraction. The edges represent transitions between cell types, the width of the edges correspond to the number of times the transition occurred on the logarithmic scale. The number of transitions towards a different or the original cell type were counted for both activations and inactivations.