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. 2015 Jun 19;10(6):e0128517. doi: 10.1371/journal.pone.0128517

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© 2015 Sun, Yi

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 2 — (A) The emission probability matrix indicating the composition of 6 histone modifications in each state. Candidate annotation for each chromatin state is also presented. (B) DNA methylation levels of CpGs located in different chromatin states. Data (mean fractional methylation levels ± standard error) from three individuals (a newborn as well as a 25-year-old and 82-year-old individual) are presented. In total, 1,000 CpGs were randomly chosen for each state. (C) Enhancers residing in distal intergenic regions (states EnhWk and EnhAc) are significantly hypo-methylated compared with nearby regions. The position 0 indicates the focal enhancer, and the levels of DNA methylation up to 2 kb from the enhancers in either direction are presented (200-bp bin size).