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. Author manuscript; available in PMC: 2016 Jun 18.
Published in final edited form as: Mol Cell. 2015 Jun 18;58(6):959–969. doi: 10.1016/j.molcel.2015.01.037

Figure 2. The role of PARPs in RNA binding.

Figure 2

(a) Schematic diagram of PARPs that contain RNA binding domains. PARPs are drawn to scale to highlight similarities in the spacing and length of CCCH zinc finger domains.

(b) Analysis of all human proteins that contain CCCH domains. Function of individual proteins was classified into the indicated categories. Proteins containing these domains function in nearly all aspects of RNA biology.

(c) Functional classification of ADP-ribose associated proteins identified in proteomic studies. The type of ADP-ribose purification method utilized in each study is shown in red. Proteins identified in these studies were analyzed by GO term analysis, and categories relevant to RNA biology shown. The size of the circle is inversely correlated with the p-value of the enrichment, e.g. the smaller the p-value the larger the circle. Scale bar in the first circle represents a p-value of 1-10.