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. Author manuscript; available in PMC: 2015 Jun 20.
Published in final edited form as: Ageing Res Rev. 2013 Jan 24;12(3):815–822. doi: 10.1016/j.arr.2013.01.005

Figure 1. Reelin is anatomically poised to modulate neurotransmission at excitatory and inhibitory synapses on dentate granule neurons.

Figure 1

Histological section shows immunofluorescent detection of reelin (green), synaptophysin (red), with nuclei counterstained with DAPI (blue). Schematic shows hippocampal circuitry represented in terms of the synaptic sites for reelin release. Inset on schematic shows a possible model for partitioning of reelin signaling; we speculatively propose that the reelin receptor very-low density lipoprotein receptor (VLDLR) segregates to inhibitory postsynaptic contacts where reelin is released from interneurons residing in the stratum lacunosum-moleculare. This would likely lead to distinct consequences relative to reelin released at excitatory terminals arising from entorhinal neurons, which would signal in concert with glutamate via the postsynaptic complex made up of apolipoprotein E receptor 2 (APOER2) and the N-methyl-D-aspartate receptor (NMDAr).