Table 7.
Sample sizes required for alternative designs using classical power calculations.
Study Design | Sample Size by Power
|
||
---|---|---|---|
80% | 85% | 90% | |
A: Proposed design | 20,228 | 23,138 | 27,078 |
B: Hard CVD | 42,834 | 48,998 | 57,342 |
C: All CHD | 22,026 | 25,196 | 29,488 |
D: Death or any CHD | 30,764 | 35,190 | 41,184 |
E: Death or any CVD | 26,856 | 30,722 | 35,954 |
F: CAC cutpoints 0/300 | 21,760 | 24,892 | 29,130 |
G: CAC cutpoints 10/100 | 23,972 | 27,420 | 32,090 |
H: CAC cutpoints 10/300 | 25,966 | 29,702 | 34,760 |
I: FRS of 0.04/0.75/0.2/0.01 | 19,076 | 21,820 | 25,536 |
J: Simvastatin | 27,448 | 31,398 | 36,744 |
K: Simvastatin with min 10 mg | 27,880 | 31,892 | 37,324 |