Table 2.
All-cause mortality of ICU patients with S. aureus or P. aeruginosa pneumonia versus controls
| Cohorts of interest | Comparisons | ||||||
|---|---|---|---|---|---|---|---|
| S. aureus pneumonia vs No pneumonia | P. aeruginosa pneumonia vs No pneumonia | ||||||
| No pneumonia (n = 201,394) | S. aureus pneumonia (n = 2275) | P. aeruginosa pneumonia (n = 1007) | Odds Ratio/Differencea (95 % CI) | P Valuea | Odds Ratio/Differenceb (95 % CI) | P Valueb | |
| Index hospitalization mortality | |||||||
| No. (%) of patients | 6,188 (3.1) | 363 (16.0) | 203 (20.2) | 5.99 (5.34, 6.72) | <.001 | 7.97 (6.81, 9.31) | <.001 |
| Post-index mortality | |||||||
| No. (%) of patients | 5,609 (2.8) | 227 (10.0) | 117 (11.6) | 3.87 (3.37, 4.45) | <.001 | 4.59 (3.78, 5.57) | <.001 |
| Mean (SD) time to deathc | 32.8 (27.1) | 25.5 (25.8) | 28.1 (28.4) | -7.30 (-10.51, -3.63) | <.001 | -4.69 (-9.44, 1.02) | .10 |
| Survival rate: | 3.75 (3.28, 4.28) | <.001 | 4.40 (3.66, 5.28) | <.001 | |||
| 30 days (%) | 98.5 | 93.4 | 92.9 | ||||
| 90 days (%) | 97.2 | 90.0 | 88.4 | ||||
| Index + post-index mortality | |||||||
| No. (%) of patients | 11,797 (5.9) | 590 (25.9) | 320 (31.8) | 5.63 (5.11, 6.19) | <.001 | 7.49 (6.55, 8.56) | <.001 |
| Mean (SD) time to deathc | 24.9 (28.3) | 46.4 (47.6) | 63.5 (59.3) | 21.53 (17.39, 26.07) | <.001 | 38.57 (31.08, 47.07) | <.001 |
CI confidence interval, ICU intensive care unit
aOdds ratio (OR) from Chi-square test is used for categorical variables, negative binomial models are used to test for differences between means for count variables (number of events and length of stay). Statistical comparisons are comparing Cohort 3 (pneumonia due to S. aureus) with Cohort 1 (no pneumonia, reference group); ie, Difference = mean (Cohort 3) − mean (Cohort 1) and OR = Odds (Cohort 3)/Odds (Cohort 1)
bOdds ratio (OR) from Chi-square test is used for categorical variables, negative binomial models are used to test for differences between means for count variables (number of events and length of stay). Statistical comparisons are comparing Cohort 4 (pneumonia due to P. aeruginosa) with Cohort 1 (no pneumonia, reference group); i.e., Difference = mean (Cohort 4) − mean (Cohort 1) and OR = Odds (Cohort 4)/Odds (Cohort 1)
cIncluding only patients with mortality