Table 4.
Linear regression analysis for risk factors for decreased estimated glomerular filtration rate
| Parameters | Univariable | Multivariable | ||
|---|---|---|---|---|
| B (95 % CI) | P value | B (95 % CI) | P value | |
| Age (yr) | -1.14 (-1.3 to -0.9) | <0.001 | -0.5 (-0.66 to -0.33) | <0.001 |
| Gender | 1.97 (-4.4 to 8.3) | 0.54 | ||
| Hypertension | -21.1 (-28.1 to -14.1) | <0.001 | ||
| Initial eGFR (mL/min/1.73 m2) | 0.67 (0.6 to 0.7) | <0.001 | 0.3 (0.22 to 0.38) | <0.001 |
| Hemoglobin (g/dL) | 6.86 (5.1 to 8.6) | <0.001 | 2.91 (1.61 to 4.21) | <0.001 |
| Uric acid (mg/dL) | -8.84 (-10.7 to -6.95) | <0.001 | -4.22 (-5.66 to -2.78) | <0.001 |
| HtTKV (mL/m) | -18.8 (-22.6 to -15.0) | <0.001 | -5.6 (-8.57 to -2.63) | <0.001 |
| Albumin/Cr (mg/g) | -11.2 (-13.3 to -9.12) | <0.001 | -3.31 (-4.99 to -1.64) | <0.001 |
| Urinary AGT/Cr (μg/g) | -9.5 (-11.8 to -7.19) | <0.001 | -1.63 (-3.74 to 0.48) | 0.1 |
In multivariate analysis, data were adjusted for age, hypertension, initial eGFR, plasma hemoglobin, serum uric acid, htTKV, random urine albumin-to-creatinine ratio, and urinary AGT/Cr by stepwise selection method. HtTKV, albumin/Cr, and AGT/Cr were log-transformed to fulfill the requirement of normal distribution of residuals. AGT angiotensinogen, Cr creatinine, eGFR estimated glomerular filtration rate, htTKV height-adjusted total kidney volume