Table 3.
Drugs warranting clinical summaries for implementation per modified AGREE guideline assessment
| Drug | Variant | Method of identification1 | Modified AGREE II Scores2 | |||||
|---|---|---|---|---|---|---|---|---|
| Domain 1 Scope | Domain 3 Rigour | Domain 4 Clarity | Domain 5 Applicability | Overall Quality Score, Averaged | Recommended for Implementation | |||
| Amlodipine | rs2238032 | Candidate gene | 90.7 | 64.8 | 72.2 | 61.1 | 5.33 | Yes |
| rs2239050 | Candidate gene | 90.7 | 64.8 | 72.2 | 61.1 | 5.33 | Yes | |
| rs2239128 | Candidate gene | 90.7 | 63.0 | 66.7 | 61.1 | 5.33 | Yes | |
| rs2246709 | Candidate gene | 85.2 | 70.4 | 50.0 | 50.0 | 4.33 | Yes | |
| Aspirin | rs730012 | Candidate gene | 87.0 | 74.1 | 57.4 | 61.1 | 5.33 | Yes |
| Atenolol | rs688 | Candidate gene | 74.1 | 66.7 | 57.4 | 63.9 | 3.67 | Yes |
| rs699 | Candidate gene | 87.0 | 72.2 | 63.0 | 63.9 | 4.33 | Yes | |
| rs5051 | Candidate gene | 87.0 | 72.2 | 63.0 | 63.9 | 4.33 | Yes | |
| rs5443 | Candidate gene | 85.2 | 70.4 | 63.0 | 63.9 | 5.33 | Yes | |
| rs1801252/rs1801253 | Candidate gene | 88.9 | 68.5 | 70.4 | 61.1 | 5.33 | Yes | |
| rs2301339 | Candidate gene | 85.2 | 70.4 | 63.0 | 63.9 | 5.33 | Yes | |
| rs11064426 | Candidate gene | 85.2 | 70.4 | 63.0 | 63.9 | 5.33 | Yes | |
| Atorvastatin | rs5443 | Candidate gene | 88.9 | 66.7 | 51.9 | 52.8 | 4.67 | Yes |
| rs20455 | Candidate gene | 98.1 | 74.1 | 79.6 | 69.4 | 6.00 | Yes | |
| rs4149056 | Candidate gene | 87.0 | 63.0 | 44.4 | 58.3 | 3.67 | Yes | |
| Benazepril | rs7079 | Candidate gene | 87.0 | 66.7 | 63.0 | 58.3 | 5.00 | Yes |
| rs1799752 | Candidate gene | 94.4 | 81.5 | 68.5 | 63.9 | 5.33 | Yes | |
| rs1799998 | Candidate gene | 88.9 | 70.4 | 63.0 | 61.1 | 5.00 | Yes | |
| rs1801133 | Candidate gene | 85.2 | 51.9 | 46.3 | 50.0 | 3.67 | Yes | |
| Candesartan | rs1799998 | Candidate gene | 87.0 | 59.3 | 55.6 | 63.9 | 4.00 | Yes |
| Carvedilol | rs1042714 | Candidate gene | 98.1 | 81.5 | 70.4 | 63.9 | 6.00 | Yes |
| rs1801253 | Candidate gene | 92.6 | 77.8 | 74.1 | 66.7 | 5.67 | Yes | |
| Clopidogrel | CYP2C19 | GWAS + Candidate gene | 100 | 96.3 | 100 | 91.7 | 7.00 | Yes |
| rs1045642 | Candidate gene | 98.1 | 87.0 | 79.6 | 72.2 | 6.00 | Yes | |
| Dabigatran | rs2244613 | GWAS | 98.1 | 98.1 | 85.2 | 83.3 | 6.33 | Yes |
| Felodipine | rs2238032 | Candidate gene | 90.7 | 64.8 | 72.2 | 61.1 | 5.33 | Yes |
| rs2239050 | Candidate gene | 90.7 | 64.8 | 66.7 | 61.1 | 5.33 | Yes | |
| rs2239128 | Candidate gene | 90.7 | 64.8 | 66.7 | 61.1 | 5.33 | Yes | |
| Fenofibrate | rs320 | Candidate gene | 92.6 | 57.4 | 63.0 | 55.6 | 4.00 | Yes |
| rs676210 | Candidate gene | 92.6 | 72.2 | 66.7 | 61.1 | 5.33 | Yes | |
| rs2727786 | Candidate gene | 90.7 | 53.7 | 59.3 | 58.3 | 3.67 | Yes | |
| Fluvastatin | rs1799752 | Candidate gene | 96.3 | 66.7 | 63.0 | 58.3 | 5.33 | Yes |
| rs11045819 | Candidate gene | 96.3 | 72.2 | 72.2 | 66.7 | 5.33 | Yes | |
| Hydralazine | rs1799983 | Candidate gene | 100 | 79.6 | 85.2 | 80.6 | 6.33 | Yes |
| rs1799998 | Candidate gene | 100 | 79.6 | 85.2 | 80.6 | 6.33 | Yes | |
| HCTZ | rs4961 | Candidate gene | 96.3 | 72.2 | 57.4 | 58.3 | 4.67 | Yes |
| rs11240688 | Candidate gene | 96.3 | 75.9 | 63.0 | 61.1 | 4.67 | Yes | |
| Irbsartan | rs1367117 | Candidate gene | 74.1 | 66.7 | 57.4 | 63.9 | 3.67 | Yes |
| rs1799752 | Candidate gene | 90.7 | 72.2 | 64.8 | 63.9 | 4.33 | Yes | |
| Metoprolol | CYP2D6 | Candidate gene | 100 | 100 | 98.1 | 97.2 | 7.00 | Yes |
| rs1024323 | Candidate gene | 92.6 | 75.9 | 57.4 | 61.1 | 4.33 | Yes | |
| rs1801253 | Candidate gene | 83.3 | 55.6 | 53.7 | 58.3 | 4.33 | Yes | |
| Nifedipine | rs2238032 | Candidate gene | 92.6 | 64.8 | 66.7 | 61.1 | 5.33 | Yes |
| Perindopril | rs1799752 | Candidate gene | 96.3 | 77.8 | 70.4 | 66.7 | 5.00 | Yes |
| Pravastatin | rs4149056 | Candidate gene | 96.3 | 74.1 | 51.9 | 61.1 | 4.00 | Yes |
| rs17238540 | Candidate gene | 96.3 | 81.5 | 74.1 | 72.2 | 6.00 | Yes | |
| rs17244841 | Candidate gene | 96.3 | 81.5 | 68.5 | 72.2 | 5.67 | Yes | |
| rs4986790 | Candidate gene | 96.3 | 83.3 | 74.1 | 72.2 | 6.00 | Yes | |
| Rosuvastatin | rs2231142 | Candidate gene | 98.1 | 77.8 | 74.1 | 69.4 | 6.00 | Yes |
| Simvastatin | rs2032582 | Candidate gene | 88.0 | 63.0 | 51.9 | 61.1 | 4.00 | Yes |
| rs4149056 | GWAS | 98.1 | 92.6 | 92.6 | 77.8 | 6.33 | Yes | |
| Verapamil | rs1801252/rs1801253 | Candidate gene | 98.1 | 81.5 | 81.5 | 72.2 | 6.00 | Yes |
| Warfarin | All variants | GWAS + Candidate gene | 100 | 100 | 92.6 | 97.2 | 7.00 | Yes |
| Average | 91.9 | 73.1 | 67.8 | 65.8 | 5.18 | |||
| SD | 6.1 | 11.1 | 12.5 | 10.0 | 0.91 | |||
| Range | 74.1–100 | 51.9–100 | 44.4–100 | 50.0–97.2 | 3.67–7.00 | |||
1
Genome-wide association study (GWAS), Candidate gene
2
Brouwers M, et al. AGREE II: Advancing guideline development, reporting and evaluation in healthcare. Can Med Assoc J. 2010.