Table IV.
Odds ratio (OR) of higher serum total PSA concentration by quintile of serum total testosterone concentration, 378 men, 40-85 years old, NHANES 2001-2004
| Quintile of serum total testosterone concentration (ng/mL) | N | OR of higher serum total PSA concentration (95% CI) |
|
|---|---|---|---|
| Age and race/ethnicity adjusted* | Multivariable adjusted† | ||
| PSA concentration > 4.0 ng/mL (5.2%) | |||
| < 3.16 | 89 | 1.00 (reference) | 1.00 (reference) |
| 3.16 - < 4.04 | 75 | 2.14 (0.45, 10.14) | 1.98 (0.34, 11.71) |
| 4.04 - < 4.88 | 61 | 5.85 (0.71, 47.96) | 5.43 (0.42, 70.95) |
| 4.88 - < 6.02 | 75 | 5.88 (1.32, 26.21) | 6.61 (1.22, 35.65) |
| ≥ 6.02 | 78 | 7.04 (1.23, 40.36) | 5.54 (0.49, 62.90) |
| Per quintile increase | 1.57 (1.07, 2.31) | 1.56 (0.95, 2.56) | |
| P-trend‡ | 0.02 | 0.10 | |
| PSA concentration ≥ 2.5 ng/mL (11.3%) | |||
| < 3.16 | 89 | 1.00 (reference) | 1.00 (reference) |
| 3.16 - < 4.04 | 75 | 1.63 (0.47, 5.60) | 1.71 (0.46, 6.40) |
| 4.04 - < 4.88 | 61 | 2.66 (0.62, 11.54) | 3.41 (0.55, 21.08) |
| 4.88 - < 6.02 | 75 | 3.08 (0.98, 9.67) | 4.88 (1.17, 20.32) |
| ≥ 6.02 | 78 | 6.33 (2.23, 17.99) | 11.14 (1.84, 67.29) |
| Per quintile increase | 1.54 (1.18, 2.01) | 1.78 (1.16, 2.73) | |
| P-trend‡ | 0.001 | 0.006 | |
| PSA concentration ≥ 2.0 ng/mL (15.8%) | |||
| < 3.16 | 89 | 1.00 (reference) | 1.00 (reference) |
| 3.16 - < 4.04 | 75 | 1.17 (0.26, 5.30) | 1.10 (0.23, 5.16) |
| 4.04 - < 4.88 | 61 | 3.58 (0.64, 20.17) | 3.79 (0.61, 23.60) |
| 4.88 - < 6.02 | 75 | 2.08 (0.33, 13.06) | 2.66 (0.45, 15.81) |
| ≥ 6.02 | 78 | 3.62 (0.73, 17.86) | 4.48 (0.74, 27.16) |
| Per quintile increase | 1.35 (0.95, 1.91) | 1.44 (0.97, 2.12) | |
| P-trend‡ | 0.08 | 0.08 | |
Adjusted for age in years (spline) and race/ethnicity (NH White, NH Black, Hispanic, Other).
Adjusted for age in years (spline), race/ethnicity (NH White, NH Black, Hispanic, Other), body mass index (categorical), waist circumference (continuous), cigarette smoking status (non-smoker, former smoker, current smoker), type II diabetes (non-diabetic, pre-diabetic, diabetic), estradiol (continuous, natural logarithm-transformed), sex hormone binding globulin (continuous, natural logarithm-transformed).
P-trend calculated modeling the natural logarithm-transformed PSA concentration and median total testosterone concentration by quintile.