III.

Logistic Regression Model Correlating PTEN With ECE, SV, and Gleason Score

Endpoint	Parameter	Comparison	Odds ratio	95% LCL	95% UCL	Pairwise P-value	Overall P-value
Extra-capsular invasion (yes, no)	PTEN	Homo vs. no del	3.45	1.97	6.06	<0.0001	<0.0001
		Hemi vs. no del	1.49	0.79	2.70	0.20
	PTEN	Any del vs. no del	2.32	1.51	3.57	<0.0001
Seminal vesicle invasion (yes, no)	PTEN	Homo vs. no del	4.33	1.87	9.43	0.0003	0.002
		Hemi vs. no del	2.49	0.89	6.07	0.06
	PTEN	Any del vs. no del	3.39	1.70	6.62	0.0004
Gleason
(≤6, 7, ≥8)	PTEN	Homo vs. no del	3.37	1.83	6.19	<0.0001	<0.0001
		Hemi vs. no del	1.54	0.82	2.89	0.23
	PTEN	Any del vs. no del	2.32	1.55	3.48	<0.0001