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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Clin Ther. 2015 May 29;37(6):1340–1351. doi: 10.1016/j.clinthera.2015.05.006

Table V.

Baseline parameter estimations using final pharmacokinetic model.*

Variable Controls (n = 87) Cases (n = 87) P
Serum creatinine, mg/dL 0.48 (0.20) [0.30–0.60] 0.51 (0.22) [0.34–0.67] 0.2
Clearance, L/kg/h 0.12 (0.03) [0.10–0.15] 0.11 (0.04) [0.08–0.14] 0.003
Vd, L/kg 0.58 (0.08) [0.53–0.61] 0.56 (0.06) [0.53–0.60] 0.3
Half-life, h 3.4 (0.8) [2.8–3.9] 4.1 (1.7) [2.9–4.8] <0.001
Elimination rate constant, h−1 0.21 (0.05) [0.18–0.25] 0.19 (0.06) [0.14–0.24] 0.002
*

Data are presented as mean (SD) [interquartile range].