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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Trends Cell Biol. 2015 Mar 17;25(7):408–416. doi: 10.1016/j.tcb.2015.02.005

Figure 2. AP-2 binding to cargo and PI(4,5)P2 membranes triggers recruitment of clathrin.

Figure 2

(A) The recent structure of the AP-2 core complex in the closed conformation revealing an autoinhibitory interaction with the clathrin box motif (orange) of the β2 subunit [55]. (B) The structure of the AP-2 core complex in the open conformation demonstrating that the binding site for the clathrin box is no longer present [29], consequently the clathrin box is available to recruit clathrin. (C) Model for activation of AP-2 by binding to cargo and PI(4,5)P2, leading to recruitment of clathrin through the released clathrin box motif [55].