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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Trends Cell Biol. 2015 Mar 17;25(7):408–416. doi: 10.1016/j.tcb.2015.02.005

Figure 4. The exomer cargo adaptor remodels the membrane.

Figure 4

(A) Normal mode analysis was used to model the hinge motion of the Exomer/Arf1 complex [88]. The hinge motion of the exomer complex has been established [86]. (B) Schematic of the dual roles of exomer in biogenesis of a secretory vesicle: cargo sorting and membrane remodeling. (C) Structural model of several Exomer/Arf1 complexes on the constricted neck of a budding vesicle. One-half of a tangential cross-section of the budding vesicle neck is shown for clarity. The myristoylated N-terminal amphipathic helix of each Arf1 molecule is modeled based on a previous study [90].