Table 1.

Disease-susceptible inbred rat strains commonly used for cardiovascular research.

Strain	Designation	Phenotype(s)	Ref (PMID)
Dark Agouti	DA/OlaHsd	Increased aerobic running capacity; Increased cardiac output; increased heart rate; Increased heart weight	12079278
Fawn Hooded Hypertensive	FHH/Eur	Impaired myogenic response; Abnormal kidney physiology; Increased systemic arterial blood pressure; Increased urine protein level, Pulmonary hypertension	9887194, 9184548
Genetically Hypertensive	GH/Omr	Abnormal blood vessel morphology; Hypertension; Increased mean systemic arterial blood pressure; Increased systemic arterial blood pressure	4593562
Goto Kakizaki	GK/KyoSwe	Cortical renal glomerulopathies; Circulating insulin level; Impaired glucose tolerance; Increased body weight; Increased circulating glucose level	8528248
Inherited stress-induced arterial hypertension	ISIAH	Increased circulating corticosterone level; Increased mean systemic arterial blood pressure; Increased response of heart to induced stress; Increased systemic arterial systolic blood pressure	4040537
Lyon hypertensive	LH/MavRRRC	Hyperlipidemia; Increased body weight; Increased systemic arterial blood pressure	9247739
Milan hypertensive strain	MHS/N	Decreased kidney weight; Increased heart rate, Increased left ventricle weight, Increased systemic arterial blood pressure	8846504, 16278339
Milan normotensive strain	MNS	Decreased systemic arterial blood pressure; Glomerulosclerosis	8846504, 16278339
Prague hypertensive/normotensive strains	PHR, PNR	Mild hypertension	8401416, 2264160
Sabra hypertension prone	SBH/Ygl	Increased circulating creatinine level, Increased renal glomerular filtration rate, Increased systemic arterial blood pressure; Increased urine protein level, Salt-sensitive hypertension	8906515
Salt sensitive	SS/Jr	Albuminuria; Cardiac fibrosis; Enlarged heart; Heart left ventricle hypertrophy; Hyperlipidemia; Hypertension; Increased systemic arterial blood pressure; Increased urine protein level; Insulin resistance	6754600
Spontaneoulsy hypertensive rat	SHR	Increased systemic arterial blood pressure; Abnormal cardiac stroke volume; Increased circulating glucose level	13939773, 13939773, 3596765
Spontaneously hypertensive heart failure rats	SHHF/Bbb	Congestive heart failure; Increased systemic arterial systolic blood pressure	18443590
Spontaneously hypertensive rats, stroke prone	SHRSP	Abnormal cardiac stroke volume; Decreased body weight; Hypertension; Increased systemic arterial blood pressure; Stroke; proteinuria; Cardiovascular abnormalities	4454512
Zucker Diabetic Fatty rat	ZDF	Decreased circulating insulin level; Increased circulating glucose level; Obese; Increased susceptibility to autoimmune diseases; Vasculitis	2786848

PMID; Pubmed ID