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Screening of a targeted library of nucleosides and analogs. (A) Dose-response curves were measured for the five canonical deoxyribonucleosides, with only dGuo showing significant inhibition. (B) Dose-response curves were measured for a variety of structural analogs of dGuo. Of these, only AcGuo showed similar inhibition to the dGuo. (C) Structures and calculated IC50 values for dGuo and the other guanine analogs.
