Event related functional MRI of tics. Statistical parametric maps superimposed on axial (A), coronal (B) and sagittal (C and D) views are shown. The upper row shows significant activations (P < 0.05, corrected for multiple comparisons) of paralimbic areas (ACC and insular region bilaterally) before tic onset; these activations were much less prominent at tic onset (lower row). From Bohlhalter S, Goldfine A, Matteson S et al. Neural correlates of tic generation in Tourette syndrome: an event-related functional MRI study. Brain 2006;129:2029–2037, with permission.