Brain areas with decreased binding of [11C]flumazenil in Tourette syndrome patients versus control subjects: the most significant decreases were seen in the bilateral ventral striatum (VS), bilateral thalamus (Th), right insula (Ins) and bilateral amygdala (Amg). From Lerner A, Bagic A, Simmons JM, et al. Widespread abnormality of the gamma-aminobutyric acid-ergic system in Tourette syndrome. Brain 2012;135:1926–1936, with permission.