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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: J Hepatol. 2015 Feb 24;63(1):191–198. doi: 10.1016/j.jhep.2015.02.030

Fig. 3. Foxo3A modulates apoptosis of hepatocytes.

Fig. 3

(A) Expression levels of Foxo3A and BIM in human hepatocytes transfected with empty vector (EV), Foxo3A, or Foxo3A without DNA binding domain (Foxo3A-del). (B) Immunoblot analysis of Foxo3A, pro-caspase 3 (Pro-casp3), cleaved-caspase 3 (Cl casp3), and β-actin in human hepatocyte transfected with EV, Foxo3A, or Foxo3A-del. Cl casp3/β-actin represents a fold expression of Cl casp3 compared to control (EV) after normalized by β-actin. (C) Expression levels of Foxo3A, pro-caspase 3, cleaved-caspase 3, and β-actin in human hepatocyte transfected with EV or Foxo3A in the presence or absence of Wnt3. p-value was calculated using student t test. *, p < 0.05 vs. control (EV) (n = 3 independent experiments, assayed in triplicate).