Fig. 2.

¹H 500 MHz NMR spectra of CSF at pH 2.5 scaled according to internal standard peak (TSP) illustrating qualitative differences between single examples of untreated NL_Control (top), treated SA_Control (middle) and TBM cases (bottom). [Assignments (ppm): 1 isoleucine/leucine (0.94t/0.95d), 2 valine/isoleucine (1.00d/1.01d), 3 valine (1.04d), 4 propylene glycol (1.13d), 5 ethanol (1.17d, 3.64q), 6 3-hydroxybutyrate (1.23d, 2.53q), 7 ¹³C lactate (1.30d, 1.52d), 8 threonine/3-hydroxyisovalerate (1.33d/1.33s), 9 lactate(1.41d, 4.36q), 10 alanine (1.51d), 11 pyruvate (1.56s, 2.37s), 12 lysine (1.73 m), 13 unknown, 14 acetate (2.08s), 15 glutamine (2.16m, 2.47m), 16 acetone (2.22s), 17 citrate (2.91AB), 18 creatine (3.05s, 4.10s), 19 creatinine (3.13s, 4.29s), 20 choline (3.19s), 21 glucose (3.23dd, 3.3–3.9, 4.64d, 5.22d), 22 betaine/myo-inositol (3.27s/3.27t), 23 myo-inositol (4.05t)]. Multiplicity of peak(s): s singlet, d doublet, dd double duplet, t triplet, q quartet, m multiplet, AB AB system