Table 1.
Botanical names, families, part used, yields, and antiproliferative activity on human hepatoma cell line (HepG2) of the 23 methanol extracts of the medicinal plant selected from Thai/Lanna medicinal recipe database “MANOSROI III.”
| Plant number | Name of the medicinal plant | Family | Part used | Yield (w/w%) | Voucher specimen number | Local name | English name | Antiproliferative activity on Hep G2 | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 (µg/mL) | Folds of | NCI criteria | Rank | |||||||||
| C | D | |||||||||||
| 1 | Acanthus ebracteatus Vahl | Acanthaceae | Stem | 11.50 | MANOSROI#0033 | Ngueak Pla Moh | Sea holly | >1000 | ND | ND | IA | 15 |
| 2 | Aegle marmelos (L.) Correa ex Roxb. | Rutaceae | Fruit | 43.88 | MANOSROI#0034 | Ma Toom | Bael | >1000 | ND | ND | IA | 15 |
| 3 | Albizia chinensis (Osbeck) Merr. | Leguminosae-Mimosoideae | Wood | 5.79 | MANOSROI#0021 | Kang Luang | Silk tree | 34.50 | 0.77 | 0.02 | MA | 7 |
| 4 | Caesalpinia sappan L. | Caesalpiniaceae | Wood | 14.23 | MANOSROI#0022 | Nam Khong, Fang | Sappan tree | 20.12 | 1.31 | 0.03 | MA | 3 |
| 5 | Cassia fistula L. | Leguminosae | Wood | 6.71 | MANOSROI#0012 | Ratcha Phruek | Golden shower | 372.23 | 0.07 | 0.00 | IA | 11 |
| 6 | Fibraurea tinctoria Lour. | Menispermaceae | Wood | 7.04 | MANOSROI#0035 | Kamphaeng Ched Chan | — | 89.11 | 0.30 | 0.01 | MA | 9 |
| 7 | Gloriosa superba L. | Colchicaceae | Root | 7.92 | MANOSROI#0036 | Dong Dueng | Flame lily | 20.11 | 1.31 | 0.03 | MA | 2 |
| 8 | Hydnophytum formicarum Jack | Rubiaceae | Bulb | 17.06 | MANOSROI#0037 | Hua Roi Ru | Ant plant | 129.02 | 0.20 | 0.00 | IA | 10 |
| 9 | Nymphoides indica Ktze. | Gentianaceae | Wood | 8.37 | MANOSROI#0025 | Tab Tao Yai | Water snowflake | >1000 | ND | ND | IA | 15 |
| 10 | Peltophorum pterocarpum (DC.) Backer ex K. Heyne | Leguminosae-Caesalpinoideae | Wood | 10.52 | MANOSROI#0023 | San Ngoen | Copper pod | 395.01 | 0.07 | 0.00 | IA | 13 |
| 11 | Polyalthia debilis Pierre Finet et Gagnep. | Annonaceae | Wood | 5.96 | MANOSROI#0024 | Kluay Tao, Tab Tao | — | >1000 | ND | ND | IA | 15 |
| 12 | Pouzolzia pentandra Benn. | Urticaceae | Leaf | 5.54 | MANOSROI#0045 | Kob Cha Nang Dang | — | 35.51 | 0.74 | 0.02 | MA | 8 |
| 13 | Psocarpus tetragonolobus (L.) DC. | Leguminosae-Papilionoideae | Rhizome | 10.07 | MANOSROI#0003 | Thua Phu | Winged bean | >1000 | ND | ND | IA | 15 |
| 14 | Rhinacanthus nasutus (L.) Kurz | Acanthaceae | Whole | 8.61 | MANOSROI#0038 | Thong Phan Chang | Snake jasmine | 30.91 | 0.85 | 0.02 | MA | 6 |
| 15 | Senna alata (L.) Roxb. | Leguminosae-Caesalpinoideae | Root | 21.52 | MANOSROI#0030 | Chumhet Thet | Candle tree | 22.46 | 1.18 | 0.02 | MA | 5 |
| 16 | Sida rhombifolia L. | Malvaceae | Root | 7.68 | MANOSROI#0020 | Ya Khat, Khat Mon | Paddy's lucerne | >1000 | ND | ND | IA | 15 |
| 17 | Smilax glabra Wall ex Roxb. | Smilaceae | Bulb | 17.05 | MANOSROI#0039 | Khao Yen Tai | China root | >1000 | ND | ND | IA | 15 |
| 18 | Smilax corbularia Kunth | Smilaceae | Bulb | 17.22 | MANOSROI#0040 | Khao Yen Nuea | Long-leaved greenbrier | >1000 | ND | ND | IA | 15 |
| 19 | Stemona collinsae Craib | Stemonaceae | Stem | 23.00 | MANOSROI#0041 | Non Tai Yak | — | 5.51 | 4.79 | 0.10 | A | 1 |
| 20 | Suregada multiflora (A. Juss.) Baill | Euphorbiaceae | Wood | 6.35 | MANOSROI#0042 | Khan Thong Phayabat | Flase lime | >1000 | ND | ND | IA | 15 |
| 21 | Tiliacora triandra Diels. | Menispermaceae | Leaf | 12.90 | MANOSROI#0043 | Thao Ya Nang | — | 487.85 | 0.05 | 0.00 | IA | 14 |
| 22 | Urceola minutiflora Pierre. (DJ. Middleton) | Apocynaceae | Vine | 9.64 | MANOSROI#0026 | Thao Muak Khao | — | >1000 | ND | ND | IA | 15 |
| 23 | Ventilago denticulata Wild. | Rhamnaceae | Stem | 4.97 | MANOSROI#0044 | Thaowal Lek | — | 20.88 | 1.26 | 0.03 | MA | 4 |
|
| ||||||||||||
| Standard | Cisplatin (C) | 26.41 | 1 | — | — | — | ||||||
| Doxorubicin (D) | 0.54 | — | 1 | — | — | |||||||
NCI criteria: the criteria indicated 3 types of activity. A: active (IC50 < 20 mg/mL), MA: moderately active (IC50 = 20~100 mg/mL), and IA: inactive (IC50 > 100 mg/mL). ND: not determined. 1 of 23 plants (4.34%) was found active (A) and 8 of 23 plants (34.78%) were found moderately active (MA).