Table 4.
Results of confirmatory association analysis between the rs2498794 SNP and smoking or cancer-related phenotypes.
| SNP | Stage | Pvalues for confirmatory and combined association analyses in genotypic/dominant/recessive models for each minor allele | |||||
|---|---|---|---|---|---|---|---|
| Cancer status (present illness) | Cancer status (present or past illnesses) | Smoking history | Smoking period (year) | CPDa | Brinkman (smoking) index | ||
| rs2498794 | confirmatory | 0.208/0.453/0.077 | 0.075/0.903/0.038∗ | 0.552/0.892/0.336 | 0.143/0.743/0.092 | 0.912/0.890/0.744 | 0.141/0.733/0.092 |
| rs2498794 | combined | 0.910/0.665/0.890 | 0.205/0.482/0.190 | 0.901/0.824/0.763 | 0.068/0.641/0.048† | 0.610/0.529/0.610 | 0.073/0.486/0.070 |
aCigarettes smoked per day.
∗Significant association between the minor T allele of the SNP and noncancer status (present or past illness) in the recessive model (P < 0.05).
†Significant association between the minor T allele of the SNP and longer periods of smoking history in the recessive model (P < 0.05).