Table 5.
Univariate and multivariate regression analysis of relationship between lncRNAs and HCC clinicopathological features.
| LncRNAs | Univariate analysis, OR (95% CI) | P value | Multivariate analysis, OR (95% CI) | P value |
|---|---|---|---|---|
| HBV infection | ||||
| H19, per increase of 1 unit | 1.143 (1.013–1.29) | 0.03 | 1.14 (1.008–1.29) | 0.037 |
| MEG3, per increase of 1 unit | 1.503 (0.949–2.383) | 0.083 | ||
| MALAT1, per increase of 1 unit | 28.164 (2.179–364.071) | 0.011 | 26.951 (2.022–359.284) | 0.013 |
|
| ||||
| Vascular invasion | ||||
| MEG3, per increase of 1 unit | 1.425 (1.034–1.963) | 0.031 | ||
| HULC, per increase of 1 unit | 0.64 (0.522–0.786) | <0.001 | 0.648 (0.523–0.803) | <0.001 |
| UCA1, per increase of 1 unit | 2.952 (0.822–10.601) | 0.097 | ||
|
| ||||
| AFP over 200 ng/mL | ||||
| H19, per increase of 1 unit | 1.526 (1.352–1.723) | <0.001 | 1.45 (1.277–1.646) | <0.001 |
| MEG3, per increase of 1 unit | 2.304 (1.584–3.351) | <0.001 | 1.613 (1.1–2.365) | 0.014 |
| HULC, per increase of 1 unit | 0.855 (0.726–1.007) | 0.06 | ||
| HOXA13, per increase of 1 unit | 0.547 (0.288–1.039) | 0.065 | ||
| KCNQ1OT1, per increase of 1 unit | 2.557 (0.992–6.592) | 0.052 | ||
HBV: hepatitis B virus; AFP: α-fetoprotein; OR: odd ratios; CI: confidence intervals.