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. 2015 Jun 21;15:477. doi: 10.1186/s12885-015-1447-y

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© Yco et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Isobologram analysis for SSZ and DFMO in NB. Isobolograms were prepared to determine synergisms between SSZ and DFMO. NB cell lines SK-N-Be(2)c and LAN-5 were used to determine the inhibitory concentration at which 50 % of cells are dead (IC₅₀) after 48 h of treatment with (a) SSZ and (b) DFMO. (c) Isobologram analysis to determine the combined cytotoxicity of SSZ and DFMO using the IC₅₀ values from (a and b). The IC₅₀ value of SSZ and DFMO used in combination provides the connective points for the line of additive. Synergy, additivity, or antagonism is indicated below, on, or above the line, respectively. The data present the average of three independent experiments in duplicate (n = 6); points, mean ± SEM