Table 1.
SPR mRNA correlations in public NB mRNA expression datasets
| Dataset | SPR mRNA expression correlations | Micro-array data | |||
|---|---|---|---|---|---|
| Name | Samples | Survival/prognosis | MYCN amplification | Array Type | GSE |
| Delattre | 64 | n.d. | positive (6.8 • 10-6) | Affymetrix HG-U133 Plus 2.0 | 12460 |
| Hiyama | 51 | negative (0.02) | positive (2.8 • 10-3) | Affymetrix HG-U133 Plus 2.0 | 16237 |
| Jagannathan | 100 | negative (0.02) | positive (1.7 • 10-3) | Illumina Human WG 6V2 | 19274 |
| Kocak | 649 | n.d. | positive (7.9 • 10-15) | Agilent Human 44K Oligo | 45547 |
| Łastowska | 30 | n.d. | positive (2.6 • 10-4) | Affymetrix HG-U133 Plus 2.0 | 13136 |
| Maris | 101 | n.d. | n.s. | Affymetrix HG-U95A | 3960 |
| Seeger | 117 | negative (1.4 • 10-4) | n.d. | Affymetrix HG-U133A | 3446 |
| Versteeg | 88 | negative (0.02) | n.s. | Affymetrix HG-U133 Plus 2.0 | 16476 |
| Zhang | 498 | negative (2.1 • 10-6) | positive (4.6 • 10-4) | Agilent Human 44K Oligo | 49710 |
Legend: The Albino-28 (GSE7529), Khan-47 (GSE27608), and Seeger-102 (GSE3446) do not contain sufficient clinical data and were not analyzed. Data were analyzed as described in the Materials and Methods. The first two columns represent name and sample size of the dataset. The two central columns show the results of SPR mRNA expression correlation analyses: with survival and/or prognosis, and with MYCN amplification. Negative or positive in the two central columns means that SPR mRNA expression correlates negative or positive with survival/good prognosis and MYCN amplification, respectively (outcomes of Kruskal-Wallis correlation tests, the number in parentheses is the P value, n.s. means not significant, n.d. means not determined (data not present in the dataset)). Kocak-649 and Zhang-498 contain some common samples. The last two columns list Array type and GEO GSE number on the NCBI GEO website where full data are available