Table 1.
Clinical characteristics of cohort patients based on infection status
| No PA/SA | SA only | PA | P-value | |
|---|---|---|---|---|
| n (%) | 14 (16.7 %) | 20 (24.1 %) | 50 (59.5 %) | - |
| Age (years) | 30.9 (±13.7) | 28.5 (±12.2) | 35.6 (±12.8) | 0.097 |
| Female sex (%) | 8 (57.1 %) | 9 (45.0 %) | 25 (50.0 %) | - |
| Number of sputum samples | 3.6 (±3.7) | 3.3 (±2.5) | 5.5 (±4.3) | 0.055 |
| Number of routine visits | 6.6 (±5.3) | 4.4 (±3.6) | 7.9 (±6.9) | 0.096 |
| BMI | 21.1 (±2.5) | 22.5 (±3.5) | 22.0 (±4.5) | 0.608 |
| FEV1 (% predicted) | 70.9 (±21.0) | 66.5 (±22.1) | 56.3 (±27.2) | 0.096 |
| FVC (% predicted) | 85.8 (±22.1) | 82.8 (±19.3) | 72.7 (±26.3) | 0.110 |
| Exacerbation rate | 0.43 | 0.20 | 1.20 | <0.02* |
| Hospitalization rate | 0.21 | 0.15 | 1.30 | <0.10 |
| Total clinical score (out of 95) | 71.1 (±14.1) | 68.6 (±10.9) | 60.8 (±14.6) | 0.017a |
| Clinical subscore (out of 45) | 35.3 (±4.6) | 35.1 (±3.3) | 33.0 (±3.8) | 0.048* |
| Radiographic subscore (out of 25) | 18.9 (±4.0) | 17.7 (±2.9) | 15.9 (±2.7) | 0.003a |
| Pulmonary function subscore (out of 25) | 18.5 (±5.1) | 18.0 (±5.1) | 15.3 (±6.2) | 0.081 |
| Complication subscore (out of 37) | 1.5 (±2.3) | 2.3 (±2.6) | 3.4 (±4.2) | 0.185 |
| CRP† | 2.50 (±3.5) | 4.8 (±3.2) | 10.6 (±10.0) | 0.005a,b |
SA = Staphylococcus aureus; PA = Pseudomonas aeruginosa; SD = standard deviation; BMI = body mass index; FEV1 = forced expiratory volume in 1 s; FVC = forced vital capacity; CRP = C-reactive protein
Data are expressed as mean (± SD) or number (% total), except for the exacerbation and hospitalization rates expressed as mean rates calculated by Poisson regression
P-values were determined using the ANOVA or Chi-squared test. For exacerbation rate and hospitalization rate, P-values were determined by a comparison with a null model
Comparisons between groups were done using Tukey’s test. Tukey’s test reported the following differences: ap < 0.05, “No PA/SA” vs. “PA”
bp < 0.05, “SA only” vs. “PA”
†CRP data was only available in a subset of patients and results in Table 2 were collected from the different groups are as follows: Group No PA/SA: 11/14; Group SA only: 16/20; Group PA: 35/50