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. 2015 Jun 21;11:35. doi: 10.1186/s12990-015-0041-2

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© Bareiss et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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At-level QUIS-induced dysesthesias are associated with enhanced neurite outgrowth that is reduced with 3 day intrathecal delivery LY294002 (LY) 14 days following injury. a Representative immunofluorescent images of cultured DRG neurons from sham (sham veh, n = 9), QUIS nongroomers (QUIS-NG veh, n = 7), QUIS groomers (QUIS-GR veh, n = 5), QUIS LY294002 (QUIS LY, n = 11) taken ipsilateral to the injection site and grooming (T12) 14 days post-surgery. b, c DRGs from QUIS nongrooming (QUIS-NG veh) and grooming (QUIS-GR veh) animals show enhanced neurite growth initiation, DRG from QUIS-GR veh animals show enhanced neurite elongation compared to sham veh and QUIS-NG veh. Short term (3 days) intrathecal delivery of LY294002 (QUIS-LY) significantly decreased the percentage of neurons with neurites and the length of neurites following QUIS injury. d DRG growth responses were enhanced in small and large neurons 14 days post injury in QUIS-GR compared to sham veh controls. DRGs from QUIS-LY animals showed significant reductions in small and large DRG growth responses (mean ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).