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. Author manuscript; available in PMC: 2015 Dec 18.
Published in final edited form as: Nature. 2015 Mar 30;522(7556):345–348. doi: 10.1038/nature14282

Extended Data Figure 6. Absence of the adaptive immune system reduces metastasis.

Extended Data Figure 6

a, Graphic representation of mammary tumor latency (left panel) and tumor growth (right panel) in lymphocyte-proficient KEP;Rag1+/− and lymphocyte-deficient KEP;Rag1−/− mice (n = 30/group). b, Levels of TGFβ1 in mammary tumors and the plasma of tumor-bearing mice (n = 6 tumor, 3 plasma). c, Quantification of metastatic burden in lungs of recipient WT or Rag1−/− mice that were transplanted with KEP mammary tumor fragments and underwent surgical removal of the primary tumor (n = 6 WT, 4 Rag1−/− mice; **p<0.01, Mann-Whitney U test). Data are mean + s.e.m.