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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Nat Immunol. 2015 May 18;16(7):766–774. doi: 10.1038/ni.3160

Figure 1. Expression and activity of AID in human B cell precursors and B-lineage ALL.

Figure 1

(a) Plot showing correlation between common somatic hypermutation targets of mAID and their alteration status in childhood ALL. On plotting the genes which are frequently bound and targeted by mAID24, against genes which are commonly deleted and amplified in childhood ALL (data from clinical trial P9906), a positive correlation was observed using a 2×2 contingency table analysis by Chi-square test with Yates’ correction. (b) SHM frequency of IGH VH region genes in single pre-B cell clones isolated from human bone marrow (n=1) and human fetal liver (n=3). SHM of variable regions of TCRVG and TCRVB measured in these cells were used as negative controls. p-values were calculated using student t-test. (c) A schematic depicting CSR in early human B cells derived from three fetal liver donors.