Table 1.
The frequencies of genotypes and alleles of FOXP3 polymorphisms in healthy control group and lung cancer patients; the frequencies of genotypes and alleles are also illustrated in patients subdivided by age of cancer onset (<55 y/o and ≥55 y/o) and type of lung cancer (non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC)); description of the data is presented in result section
| FOXP3 locus | Gender | Genotype and allele | Control group n=156 (%) | Lung cancer patients(Total) n=156 (%) | <55 y/o patients n= 36 (%) | ≥55 y/o patients n=120(%) | NSCLC patients n=123(%) | SCLC patients n=29(%) | |
|---|---|---|---|---|---|---|---|---|---|
| -2383 C/T (rs3761549) | Female (n=30) | Genotype | CC | 27 (90.0) | 25 (83.4) | 5 (71.4) | 20 (87.0) | 19 (82.6) | 6 (85.7) |
| CT | 3 (10.0) | 4 (13.3) | 2 (28.6) | 2 (8.7) | 3 (13.0) | 1 (14.3) | |||
| TT | 0.0 | 1 (3.3) | 0.0 | 1 (4.3) | 1 (4.4) | 0.0 | |||
| Allele | C | 57 (95.0) | 54 (90.0) | 12 (85.7) | 42 (91.3) | 41 (89.1) | 13 (92.9) | ||
| T | 3 (5.0) | 6 (10.0) | 2 (14.3) | 4 (8.7) | 5 (10.9) | 1 (7.1) | |||
| Male (n=126) | Genotype | C | 118 (93.7) | 110 (87.3) | 26 (89.7) | 84 (86.6) | 88 (88.0) | 18 (81.8) | |
| T | 8 (6.3) | 16 (12.7) | 3 (10.3) | 13 (13.4) | 12 (12.0) | 4 (18.2) | |||
| Allele | C | 118 (93.7) | 110 (87.3) | 26 (89.7) | 84 (86.6) | 88 (88.0) | 18 (81.8) | ||
| T | 8 (6.3) | 16 (12.7) | 3 (10.3) | 13 (13.4) | 12 (12.0) | 4 (18.2) | |||
| Both genders(total) | Allele | C | 175 (94.1) | 164 (88.2) | 38 (88.4) | 126 (88.1) | 129 (88.4) | 31 (86.1) | |
| T | 11 (5.9) | 22 (11.8) | 5 (11.6) | 17 (11.9) | 17 (11.6) | 5 (13.9) | |||
| IVS9+459 T/C(rs2280883) | Female (n=30) | Genotype | TT | 13 (43.3) | 15 (50.0) | 2 (28.6) | 13 (56.5) | 9 (39.1) | 6 (85.7) |
| TC | 13 (43.3) | 14 (46.7) | 5 (71.4) | 9 (39.1) | 13 (56.5) | 1 (14.3) | |||
| CC | 4 (13.4) | 1 (3.3) | 0.0 | 1 (4.4) | 1 (4.4) | 0.0 | |||
| Allele | T | 39 (65.0) | 44 (73.3) | 9 (64.3) | 35 (76.1) | 31 (67.4) | 13 (92.9) | ||
| C | 21 (35.0) | 16 (26.7) | 5 (35.7) | 11 (23.9) | 15 (32.6) | 1 (7.1) | |||
| Male (n=126) | Genotype | T | 71 (56.3) | 83 (65.9) | 18 (62.1) | 65 (67.0) | 65 (65.0) | 15 (68.2) | |
| C | 55 (43.7) | 43 (34.1) | 11 (37.9) | 32 (33.0) | 35 (35.0) | 7 (31.8) | |||
| Allele | T | 71 (56.3) | 83 (65.9) | 18 (62.1) | 65 (67.0) | 65 (65.0) | 15 (68.2) | ||
| C | 55 (43.7) | 43 (34.1) | 11 (37.9) | 32 (33.0) | 35 (35.0) | 7 (31.8) | |||
| Both genders(total) | Allele | T | 110 (59.1) | 127 (68.3) | 27 (62.8) | 100 (69.9) | 96 (65.8) | 28 (77.8) | |
| C | 76 (40.9) | 59 (31.7) | 16 (37.2) | 43 (30.1) | 50 (34.2) | 8 (22.2) | |||