Table 1.
Comparison of the counts of normal and dark neurons in sections of hippocampus in three experimental groups of sham, and untreated and treated rats with Alzheimer disease
| Sections | Groups | Normal neurons | Dark neurons | ||||
|---|---|---|---|---|---|---|---|
| Counts | 95% CI | P-value* | Counts | 95% CI | P- value* | ||
| CA1 | Sham vs U-AD | 28.00±14.86 vs 15.25±14.96 | 1.66 to 23.84 | < 0.05 | 8.58±13.31 vs 27.83±17.50 | -30.70 to -7.80 | < 0.05 |
| Sham vs T-AD | 28.00±14.86 vs 46.29±17.29 | -29.38 to -7.20 | < 0.05 | 8.58±13.31 vs 8.42±17.32 | -11.28 to 11.62 | ns | |
| U-AD vs T-AD | 15.25±14.96 vs 46.29±17.29 | -42.13 to -19.95 | < 0.05 | 27.83±17.50 vs 8.42±17.32 | 7.97 to 30.87 | < 0.05 | |
| CA2 | Sham vs U-AD | 22.38±13.22 vs 25.88±20.36 | -23.14 to 16.14 | ns | 7.00±9.17 vs 26.13±26.31 | -44.93 to 6.68 | ns |
| Sham vs T-AD | 22.38±13.22 vs 25.88±9.74 | -23.14 to 16.14 | ns | 7.00±9.17 vs 16.00±19.94 | -34.80 to 16.80 | ns | |
| U-AD vs T-AD | 22.88±20.36 vs 25.88±9.74 | -19.64 to 19.64 | ns | 26.13±26.31 vs 16.00±19.94 | -15.68 to 35.93 | ns | |
| CA3 | Sham vs U-AD | 10.81±12.24 vs 5.19±5.44 | -5.03 to 16.28 | ns | 18.56±16.79 vs 29.13±15.75 | -25.82 to 4.70 | ns |
| Sham vs T-AD | 10.81±12.24 vs 21.75±6.17 | -21.60 to -0.28 | < 0.05 | 18.56±16.79 vs 20.75±19.34 | -17.45 to 13.07 | ns | |
| U-AD vs T-AD | 5.19±5.44 vs 21.75±6.17 | -27.22 to -5.90 | < 0.05 | 29.13±15.75 vs 20.75±19.34 | -6.89 to 23.64 | ns | |
| CA4 | Sham vs U-AD | 4.31±9.94 vs 3.94±6.42 | -9.24 to 9.99 | ns | 19.75±13.60 vs 28.81±21.94 | -23.91 to 5.788 | ns |
| Sham vs T-AD | 4.31±9.94 vs 19.44±14.78 | -24.74 to -5.51 | < 0.05 | 19.75±13.60 vs 16.56±13.74 | -13.01 to 17.18 | ns | |
| U-AD vs T-AD | 3.94±6.42 vs 19.44±14.78 | -25.11 to -5.89 | < 0.05 | 28.81±21.94 vs 16.56±13.74 | -3.95 to 26.24 | ns | |
*
One way ANOVA with Bonferroni post-hoc test
Abbreviations: U-AD untreated Alzheimer disease group, T-AD treated Alzheimer disease group, ns not significant