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. 2015 Apr 29;156(7):2470–2481. doi: 10.1210/en.2014-2001

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Figure 2. — A low central FGF21 dose of 0.4 μg/d into WT mice causes an increase in O₂ consumption. Mice (n = 8 per group) administered icv-FGF21 have a higher metabolic rate of VO₂ (A), yet do not consume more food (vehicle, n = 8, FGF21, n = 7) (B) or have increased activity ambulatory activity (n = 14 per group) (C). Mice given the circulation-matching, 1.6-μg/d sc-FGF21 dose (vehicle, n = 6, FGF21 n = 8) do not show an increase in VO₂ consumption (D). Graphs are shown ± SEM. *, P < .05; **, P < .01; by Student's t test, food consumption not significant by repeat measures ANOVA, P = .3193.