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. 2015 Apr 15;156(7):2619–2631. doi: 10.1210/en.2014-1655

Figure 1.

Figure 1.

Effect of intra-ARC and intra-AVPV administration of rAAV-kisspeptin-AS or rAAV-EGFP in female rats. Representative images showing rAAV-EGFP spread in the AVPV (A) and ARC (B) after intra-AVPV administration are shown. Representative images showing rAAV-EGFP spread in the AVPV (C) and ARC (D) after intra-ARC administration are also shown. 3V, third ventricle; VMH, ventromedial hypothalamus. Scale bars represent 100 μm (A and C) and 200 μm (B and D), respectively. E and F, The effect of intra-AVPV or intra-ARC rAAV-EGFP and rAAV-kisspeptin-AS administration (on pnd 10) on kisspeptin-IR in the AVPV and ARC, respectively. Quantification of kisspeptin-IR in the AVPV and ARC was carried out between pnd 50 and pnd 60 by a RIA (n = 7–9 per group). Data are shown as means ± SEM. *, P < .05.