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. 2015 Apr 15;156(7):2619–2631. doi: 10.1210/en.2014-1655

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Figure 4. — The effect of intra-ARC and intra-AVPV rAAV-kisspeptin-AS administration on LH surges in rats. Representative LH surges after intra-ARC rAAV-EGFP (A) and intra-ARC rAAV-kisspeptin-AS (B) are shown. C, AUC analysis of LH surges after intra-ARC rAAV-kisspeptin-AS vs control intra-ARC rAAV-EGFP revealed a significant decrease after ARC kisspeptin knockdown. Representative LH surge for intra-AVPV rAAV-EGFP (D) and the absence of an LH surge (E) after intra-AVPV rAAV-kisspeptin-AS administration are also shown. F, Intra-AVPV rAAV-kisspeptin-AS significantly decreased proestrous LH surge incidence vs intra-AVPV rAAV-EGFP controls; only one of seven rats exhibiting a normal LH surge occurring on proestrus. There was no significant difference in incidence of LH surges occurring on proestrus after intra-ARC rAAV-kisspeptin-AS vs intra-ARC rAAV-EGFP controls (F). Results are presented as means ± SEM. *, P < .05 vs rAAV-EGFP controls (means ± SEM; n = 5–9 per group).