Table 1.
Immunohistochemical Analysis of Growth Factor Pathway Protein Expression
|
Ptch1+/−
Trp53−/− |
Ptch1C/C
Atoh1-cre |
|||
|---|---|---|---|---|
| Vehicle | Faslodex | ERβ+/+ | ERβ−/− | |
| Phospho-ERK | 23.8 ± 5.1 (n = 6) |
6.5 ± 1.0a (n = 4) |
16.3 ± 2.8 (n = 6) |
8.3 ± 1.0a (n = 6) |
| Phospho-p38 | 10.3 ± 3.5 (n = 3) |
10.0 ± 2.0 (n = 3) |
5.0 ± 2.8 (n = 6) |
5.7 ± 3.5 (n = 6) |
| Phospho-JNK | 3.0 ± 1.0 (n = 6) |
3.3 ± 0.6 (n = 4) |
2.2 ± 0.8 (n = 6) |
2.5 ± 1.2 (n = 6) |
| Phospho-AKT | 31.0 ± 12.6 (n = 4) |
7.3 ± 4.6a (n = 4) |
18.8 ± 5.6 (n = 5) |
7.0 ± 3.4a (n = 6) |
Values are mean number of immunopositive cells per 1000 cells ± SD.
a
Significant differences between mean values for control and treatment or genotype are indicated in bold.