Figure 5.
Effects of subcutaneous injections of the NK3R agonist, senktide, in blank-SAP and NK3-SAP rats. Subcutaneous senktide injections significantly reduced TCORE in blank-SAP control rats similar to senktide microinfusion directly into the MnPO (29). In contrast, subcutaneous senktide injections did not significantly reduce TCORE in rats with ablation of NK3R-expressing MnPO neurons. Data represent changes from baseline in average TCORE (± SEM; n = 6–8 rats/group). #, Significantly different from baseline in control rats; *, significantly different, control rats vs NK3-SAP rats.