Table 3.
Sensitivity, specificity, and positive and negative predictive values of the retinal indices to classify subjects with hypertensive retinopathy or CADASIL.
| Indices | Sensitivity | Specificity | PPV | NPV | ||||
|---|---|---|---|---|---|---|---|---|
| HR versus controls | CADASIL versus controls | HR versus controls | CADASIL versus controls | HR versus controls | CADASIL versus controls | HR versus controls | CADASIL versus controls | |
| AVR | 68.8 (41.4–88.9) | 54.5 (23.5–83.1) | 87.5 (61.6–98.1) | 90.9 (58.7–98.5) | 84.6 (54.5–97.6) | 85.7 (42.2–97.6) | 73.7 (48.8–90.8) | 66.7 (38.4–88.1) |
| Mean-D | 62.5 (35.5–84.7) | 99.9 (71.3–99.9) | 68.8 (41.4–88.9) | 36.4 (11.1–69.1) | 66.7 (38.4–88.1) | 61.1 (35.8–82.6) | 64.7 (38.4–85.7) | 99.9 (40.2–99.9) |
| TI | 43.8 (19.8–70.1) | 54.6 (23.5–83.1) | 75.0 (47.6–92.6) | 63.6 (30.1–88.9) | 63.6 (30.1–88.9) | 60.0 (26.4–87.6) | 57.1 (34.0–78.1) | 58.3 (27.7–84.7) |
| AVR + mean-D + TI | 68.8 (41.4–88.9) | 54.5 (23.5–83.1) | 87.5 (61.6–98.1) | 90.9 (58.7–98.5) | 84.6 (54.5–97.6) | 85.7 (42.2–97.6) | 73.7 (48.8–90.8) | 66.7 (38.4–88.1) |
Results are expressed as % (95% CI).
AVR: arteriole-to-venule ratio; HR: hypertensive retinopathy; mean-D: mean fractal dimension; NPV: negative predictive value; PPV: positive predictive value; TI: tortuosity index.