FIG 1.
Biosynthesis of lanthipeptides. (A) The mechanism of (methyl)lanthionine formation. (B) The four currently known classes of lanthipeptide synthetases. Xn represents a peptide linker. The conserved zinc-binding motifs are highlighted by the purple lines in the cyclase domains. SpaB_C is an elimination domain present as a stand-alone protein in thiopeptide biosynthesis and as the C-terminal domain of LanB enzymes in lanthipeptide biosynthesis.