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. 2015 Jun 4;81(13):4339–4350. doi: 10.1128/AEM.00635-15

FIG 1.

FIG 1

Biosynthesis of lanthipeptides. (A) The mechanism of (methyl)lanthionine formation. (B) The four currently known classes of lanthipeptide synthetases. Xn represents a peptide linker. The conserved zinc-binding motifs are highlighted by the purple lines in the cyclase domains. SpaB_C is an elimination domain present as a stand-alone protein in thiopeptide biosynthesis and as the C-terminal domain of LanB enzymes in lanthipeptide biosynthesis.