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An ML tree of LanCs and LanC-like domains. In the outer ring, the four different classes of enzymes are depicted by the color defined in the legend, whereas the different GCFs are shown in the inner ring with random colors. The GCF numbers are defined in reference 23 and can be found at http://www.igb.illinois.edu/labs/metcalf/gcf/lant.html. PKS, polyketide synthetase; NRPS, nonribosomal peptide synthetase; TOMM, thiazole/oxazole-modified microcins.
