Table 1.

Markers and Genomic Regions with LOD Scores >1.5 in Two-Point Linkage Analyses for Obesity Phenotype Variation and the Identified Candidate Genes inside the Genomic Regions

Phenotypesand Marker	ChromosomeLocation	LODScore	QTLs in Animal Models
BMI:a
D1S468	1p36 (4.2 cM from pter)	2.75	10%–13% Abdominal fat (Brockmann et al. 1998) and 16% BMI (Kovacs et al. 1997)
D2S347	2q14 (131.5 cM from pter)	4.04	Adiposity (Pomp 1997)
D2S160	2q12 (123.0 cM from pter)	2.56	1.9% Late weight gain (Cheverud et al. 1996; Vaughn et al. 1999)
D4S1592	4q12 (69.5 cM from pter)	2.29	4% 6-wk Weight gain (Keightley et al. 1996)
D6S281	6q27 (190.1 cM from pter)	1.77	6.1% Adiposity (Taylor et al. 1997)
PFM:
D2S206	2q36 (240.8 cM from pter)	1.95	Subcutaneous fat (Mehrabian et al. 1998); 10.9% body weight (Hirayama et al. 1999)
D2S347	2q14 (131.5 cM from pter)	1.91	Adiposity (Pomp 1997)
Fat Mass:
D2S347	2q14 (131.5 cM from pter)	2.03	Adiposity (Pomp 1997)
D6S281	6q27 (190.1 cM from pter)	2.02	6.1% Adiposity (Taylor et al. 1997)
D8S549	8p22 (31.7 cM from pter)	1.95	24% Body weight (Gauguier et al. 1996)
Lean Mass:
D12S83	12q14 (75.2 cM from pter)	1.79
D5S407	5q11 (64.7 cM from pter)	1.59	Adiposity (Pomp 1997)

^aCandidate genes for BMI are as follows: PGD is involved in carbohydrate metabolism. Enzyme catalyzes a step in the pentose pathway and oxidizes glucose-6-phosphate into 6-phosphoglucono-lactone (Wilson et al. 1991). TNFR2 is a polymorphism of the TNFR2 gene, which is associated with obesity, leptin levels, and insulin resistance. (Fernandez-Real et al. 2000). NR0B2 mutations are related to early-onset mild obesity (Nishigori et al. 2001). The candidate genes and their cellular functions (if indicated) in the genomic regions are identified via the human obesity gene map (Pérusse et al. 2001) or Online Mendelian Inheritance in Man. The genetic distances are as indicated by the Marshfield linkage map.